Molecular structures of spider toxins (JSTX-1, 2, 3 and 4) in the venom of Nephila clavata L. Koch

Takashi TOKI; Tadashi YASUHARA; Yoshio ARAMAKI; Yuichi HASHIMOTO; Kouichi SHUDO; Nobufumi KAWAI; Terumi NAKAJIMA

doi:10.7601/mez.41.9

Takashi TOKI, Tadashi YASUHARA, Yoshio ARAMAKI, Yuichi HASHIMOTO, Kouichi SHUDO, Nobufumi KAWAI, Terumi NAKAJIMA

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Keywords: spider toxin, JSTX, glutamate receptor blocker, Nephila clavata

JOURNAL FREE ACCESS

1990 Volume 41 Issue 1 Pages 9-14

DOI https://doi.org/10.7601/mez.41.9

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Abstract

Spider toxins in the venom of Nephila clavata L. Koch were investigated and 4 kinds of closely related toxic components, JSTX-1,2,3 and 4,were chemically characterized as follows : JSTX-1,2,4-dihydroxyphenylacetyl-asparaginyl spermine; JSTX-2,N-(2,4-dihydroxyphenylacetyl-ornithyl-asparaginyl)-N'-(putreanyl-putreanyl) cadaverine; JSTX-3,N-(2,4-dihydroxyphenylacetyl-asparaginyl)-N'-(aminopropyl-putreanyl) cadaverine; JSTX-4,N-(2,4-dihydroxyphenylacetyl-asparaginyl)-N'-(arginyl-ornityl) cadaverine. The toxins inhibited glutaminergic neurotransmission in arthropods.

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