1995 Volume 2 Issue 1 Pages 1-5
We have found a few alloantisera which react with a serologically undefined HLA-C blank specificity. At the 11th. International Histocompatibility Workshop, the tail reaction of an antiserum "BRA2O7" defined the identical specificity to our HLA-C blank specificity. We confirmed that this new specificity showed a cross reactivity with Cw8 antigen by means of an absorption test.Thus we tentatively named "Cw8N" as a potential split of HLA-Cw8. The antigen frequency was 13% in the Japanese population. Then, we analyzed the nucleotide sequence of Cw8N. As a result, the allele coding for Cw8N was identical to "Cw*0801". Furthermore, we examined association between Cw*0801 and HLA-B alleles. As for B61 alleles, B*4006 was strongly associated with Cw*0801, whereas B*4002 was associated with a different antigen Cw10. Also observed was an association between B*1502 and Cw*0801.
