1995 Volume 2 Issue 1 Pages 16-18
The lymphocytes of 46 patients with the clinical diagnosis of immune thrombocytopenic purpura (ITP) were typed for HLA class I and II antigens. The B75 and antigens were present in an increased frequency, and the B61 and Cw3 antigens in a decreased frequency compared to controls. In HLA class II antigens, DRB1* 0410, DRB1* 1301, DQB1* 0302, DQB1* 0402, DPB1* 0202, DPB1* 0601, DPB1* 1001, and DPB1* 1901 were present in an increased frequency, and DRB1* 0405, DQB1* 0303, and DPB1* 0201 in a decreased frequency compared to controls. However, only two alleles (DRB1* 0410 and DQB1* 0302) were significant (p＜0.05 X2 test), in particular, DRB1* 0410 was present in 10 of 46 patients, with a significantly increased frequency (p＜0.05). Three of these 10 DRB1* 0410 patient were homozygous and the remaining 7 ones were heterozygous for DRB1* 0410. Furthermore, the heterozygous DQB1* 0402 allele was present in 5 of these 7 DRB1* 0410 heterozygous patients. These results suggest that there is an association between HLA class II alleles (DR4 and associated antigen) and some ITP patients.
