Major Histocompatibility Complex
Online ISSN : 2187-4239
Print ISSN : 2186-9995
ISSN-L : 2186-9995
The 2016 Workshop Textbook for Certified HLA Technologists
Structures and receptor recognition mechanism of HLA molecules
Kimiko KurokiShunsuke KitaKatsumi Maenaka
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2016 Volume 23 Issue 2 Pages 80-95

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Abstract

Human Leukocyte Antigens (HLAs) are glycoproteins that exhibit unusually high genetic polymorphism as well as high polygenecity by forming a wide variety of gene families. HLAs generally display peptides derived from intracellular proteins to T cells, and furthermore, they interact with various immune cell surface receptors to control broad aspects of immune responses pleiotropically, resulting in the maintenance of homeostasis in our body. X-ray crystallography has remarkably contributed to understanding of precise mechanisms for these HLA interactions. In this issue, we describe molecular structures of HLAs and HLA-receptor complexes, showing how HLA molecules regulate immune responses, and further discuss about their relationship with diseases.

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© 2016 Japanese Society for Histocompatibility and Immunogenetics
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