Immune-mediated Necrotizing Myopathy (IMNM) and HLA Polymorphisms

Abstract

Immune-mediated necrotizing myopathy (IMNM) is a relatively newly recognized subgroup of idiopathic inflammatory myopathies. Although it has similar symptoms to polymyositis clinically, IMNM is distinguished from the other inflammatory myopathies by the absence of prominent inflammatory infiltrates histologically. IMNM has been known to be associated with myositis-specific autoantibodies such as anti-SRP and anti-HMGCR antibodies. It also may be associated with statin, malignancy and connective tissue diseases. This review provides an overview of IMNM and describes our study analyzed alleles of HLA-A, B, C, DRB1 in IMNM patients.