HLA半合致造血細胞移植後に再発した急性白血病小児患者における白血病細胞からの不適合HLAアレル喪失の検討

小野 智; 皆川 敬治; 川畑 絹代; 安田 広康; 池田 和彦; 高橋 信久; 大原 喜裕; 小林 正悟; 望月 一弘; 伊藤 正樹; 佐野 秀樹; 菊田 敦; 大戸 斉

doi:10.12667/mhc.25.34

Original paper

Loss of Mismatched HLA in Acute Leukemia Pediatric Patients after a Haploidentical Hematopoietic Stem Cell Transplantation

Satoshi Ono, Keiji Minakawa, Kinuyo Kawabata, Hiroyasu Yasuda, Kazuhiko Ikeda, Nobuhisa Takahashi, Yoshihiro Ohara, Shogo Kobayashi, Kazuhiro Mochizuki, Masaki Ito, Hideki Sano, Atsushi Kikuta, Hitoshi Ohto

Author information

Satoshi Ono
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
Keiji Minakawa
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
Kinuyo Kawabata
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
Hiroyasu Yasuda
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
Kazuhiko Ikeda
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital
Nobuhisa Takahashi
Department of Pediatric Oncology, Fukushima Medical University Hospital
Yoshihiro Ohara
Department of Pediatric Oncology, Fukushima Medical University Hospital
Shogo Kobayashi
Department of Pediatric Oncology, Fukushima Medical University Hospital
Kazuhiro Mochizuki
Department of Pediatric Oncology, Fukushima Medical University Hospital
Masaki Ito
Department of Pediatric Oncology, Fukushima Medical University Hospital
Hideki Sano
Department of Pediatric Oncology, Fukushima Medical University Hospital
Atsushi Kikuta
Department of Pediatric Oncology, Fukushima Medical University Hospital
Hitoshi Ohto
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University Hospital

Keywords: haploidentical hematopoietic stem cell transplantation, loss of HLA, graft versus leukemia effect, acute leukemia, relapse

JOURNAL FREE ACCESS

2018 Volume 25 Issue 1 Pages 34-39

DOI https://doi.org/10.12667/mhc.25.34

Details

Abstract

Recently, haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) is expected to provide a graft-versus-leukemia (GVL) effect that targets a mismatched HLA haplotype of hematological malignancies with relapse or poor prognosis. It is reported some leukemia patients who relapsed after Haplo-HSCT, lost a mismatched HLA haplotype of leukemic cells. We evaluated a loss of mismatched HLA haplotype by HLA DNA typing using blood samples obtained during relapse for 6 patients who relapsed after Haplo-HSCT. Two of 6 patients showed a loss of mismatched HLA haplotype. It is important to estimate whether the mismatched HLA haplotype derived from leukemic cells exist or not for the decision of therapeutic strategy in recurrent cases after Haplo-HSCT.

Corresponding author

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