Studies on DRBI and MLR in HLA1−haplotype matched relations.

Abstract

We examined MLR about one-mismatched HLA DRB 1 to each other, for the purpose of selection of better matching donor in the HLA one-haplotype matched relation. Each DR・DRB1 type has different strength of MLR. DR 1 DR 2 showed strong stimulation and DR 8 DR 9 did weaker one. Occurrence rate of acute rejection showed similar tendency. But DR4 subtype mismatched pairs showed high occurrence rate of acute rejection in spite of low MLR.