Analysis of HLA-DR binding peptides isolated from a T cell line, MT2

Abstract

To examine the nature of the peptides bound to HLA-DR molecules of T cells we isolated HLA-DR molecules from MT2, a human T cell lymphotropic virus-1 infected T cell line, and determined the amino acid sequence of the peptides eluted from the HLA-DR molecules. We then confirmed the binding capacity of the peptides, synthesized on the basis of the amino acid sequence obtained above, to HLA-DR transfected L cells.