Abstract
The Ishikawa Brain Imaging Study (IBIS) was initiated in 2002 to investigate the role of brain imaging for early and objective assessment of Alzheimer's disease (AD) and other forms of neurodegenerative diseases. Until now, we have studied 1365 volunteer based subjects and 590 patients with dementia using MRI and 18F-fluorodeoxyglucose PET along with neuropsychological tests and other biomarkers. We have demonstrated an age-related normalcy rate decline in volunteer based population. We also have demonstrated diverse atrophic patterns in a spectrum of AD in that a subset of patients are likely to show posterior cingulate atrophy rather than hippocampal atrophy, which is associated with greater metabolic burden. Because IBIS is a single center study, it would be important to see how such a large collection of data sets can be used in conjunction with multi-center studies such as J-ADNI.
