2016 Volume 34 Issue 1 Pages 3-7
Voxel-based morphometry (VBM) is a widely-used image analysis technique for brain morphometry using structural MR images. VBM is advantageous in that it can evaluate the whole brain objectively, without laborious and time-consuming manual intervention. It has become a major analysis technique since it was firstly applied to psychological and neurological diseases accompanying cerebral atrophy, and is now also applied to cognitive sciences fields. In this paper, VBM is summarized focusing on two essential algorithms, segmentation and normalization, including cautions and applications.