Radiogenomics Researches for Brain Diseases

Abstract

As we enter the post-genome era, with the development of next-generation sequencers, the technologies for genetic analysis have advanced dramatically along with an astonishing decline in the cost of analysis. Therefore, it is likely that genetic testing may be performed in daily clinical practice in the near future. In such an era background, a novel research field, ʻradiogenomicsʼ has been spread to offer a new viewpoint for the use of genotype in radiology and medicine research which have traditionally focused on the analysis of lesionsʼ phenotypes in medical images. This paper describes what is radiogenomics, and what is the difference between computer-aided diagnosis. Some examples of radiogenomics researches for brain diseases are also described. They are (1) estimation of cancer gene mutation by using radiomic features, (2) prognostic prediction by using cancerʼs gene and radiomic features, and (3) early detection of diseases by using personal genotype and radiomic features.