Medical Mycology Journal
Online ISSN : 2186-165X
Print ISSN : 2185-6486
Original Articles
Role of FKS Gene in the Susceptibility of Pathogenic Fungi to Echinocandins
Yasuhiro HoriKazutoshi Shibuya
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2018 Volume 59 Issue 2 Pages E31-E40

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Abstract

Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. The mechanism of echinocandin resistance involves amino acid substitutions in hot spot regions of the FKS gene product, the catalytic subunit of 1,3-β-D-glucan synthase. This resistance mechanism contributes to not only acquired resistance in Candida spp., but also inherent resistance in some pathogenic fungi. An understanding of the echinocandin resistance mechanism is important to develop both effective diagnosis and treatment options for echinocandin-resistant fungal diseases.

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© 2018 The Japanese Society for Medical Mycology
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