LC-MS/MS in clinical diagnostics: Opportunities, technical hurdles, and implementation challenges

Abstract

Mass spectrometry (MS) technology, particularly liquid chromatography-tandem mass spectrometry (LC-MS/MS), is emerging as a powerful analytical tool in clinical laboratories. This review explores the current state, challenges, and future prospects of MS integration into routine clinical testing. We discuss the unique advantages of MS, including its flexibility, specificity, and ability to perform multi-analyte measurements, which address several limitations of conventional clinical assays. However, the implementation of MS in clinical settings faces hurdles such as operational complexity, cost considerations, and regulatory challenges.

This paper examines the technical and operational issues that need to be resolved, including sample preparation, method development, and the need for specialized training. We also highlight the roles that various sectors—including education, healthcare, industry, and policy-making—must play in facilitating the widespread adoption of MS in clinical laboratories.

The potential of MS to revolutionize clinical diagnostics is significant, offering improved accuracy, expanded test menus, and new insights into disease processes. The integration of MS into clinical practice represents a crucial step in enhancing patient care and advancing medical science. This review aims to provide a comprehensive overview of the current landscape and future directions of MS in clinical laboratory testing, serving as a resource for laboratory professionals, clinicians, and researchers in this rapidly evolving field.