Improvement of T1 Determination of Hyperpolarized 129Xe in Mouse Brain under Controlled-Flow

Atsuomi KIMURA; Tetsuya WAKAYAMA; Michiko NARAZAKI; Yoko KAWATA; Tsuyoshi UEYAMA; Hideaki FUJIWARA

doi:10.2463/mrms.3.199

Technical Notes

Improvement of T₁ Determination of Hyperpolarized ¹²⁹Xe in Mouse Brain under Controlled-Flow

Atsuomi KIMURA, Tetsuya WAKAYAMA, Michiko NARAZAKI, Yoko KAWATA, Tsuyoshi UEYAMA, Hideaki FUJIWARA

Author information

Keywords: hyperpolarized ¹²⁹Xe, longitudinal relaxation time, mouse brain, controlled-flow

JOURNAL OPEN ACCESS

2004 Volume 3 Issue 4 Pages 199-205

DOI https://doi.org/10.2463/mrms.3.199

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Abstract

The method of determining the longitudinal relaxation time of hyperpolarized ¹²⁹Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1±1.6 s as the relaxation time.

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