[Paper] A CMOS Optoelectronic Neural Interface Device Based on an Image Sensor with On-chip Light Stimulation and Extracellular Neural Signal Recording for Optogenetics

Abstract

A CMOS-based optoelectronic device is proposed for on-chip neural stimulation and observation with optogenetic methodology. The device is capable of local light delivery for stimulation and electrical neural signal recording. The device consists of an array of InGaN light emitting diodes (LEDs) and Au stacked bump electrodes integrated on a CMOS image sensor. Capabilities of on-chip light stimulation and signal recording were quantitatively characterized. We have also confirmed that neuron-like cells can be cultured on the surface of the device.