Abstract
Deoxynivalenol, T2-toxin and HT-2 toxin were evaluated in the 56th JECFA (Joint FAO/WHO Expert Committee on Food Additives) held in February, 2001. The Committee proposed a PMTDI (provisional maximum tolerable daily intake) of 1 μg/kg bw/day for deoxynivalenol, based on the NOEL of 100 μg/kg bw/day in a 2-year feeding study using mice. It proposed a PMTDI of 60 ng/kg bw/day for T-2 toxin and HT-2 toxin, alone or in combination, based on the LOEL of 29 μg/kg bw/day in a 3-week dietary study in pigs. Carcinogenicity was not recognized for these trichothecens.
