2011 Volume 61 Issue 2 Pages 41-45
The extract of Eupenicillium javanicum IFM 58214 showed the antifungal activity against Aspergillus fumigatus. The active principle from E. javanicum IFM 58214 was determined to be 2-(2-carboxyethyl)-3-decylmaleic anhydride (1), by chemical and spectroscopic method. The methyl ester (2) of 1 was identified with the semi-synthetic one derived from spiculisporic acid. Semi-synthetically prepared 1 inhibited the growth of A. fumigatus, while other related compounds showed only marginal or no activity. To our knowledge, compound (1) is the first example of identification from natural sources.
