An antifungal substance isolated from Eupenicillium javanicum IFM 58214

Abstract

  The extract of Eupenicillium javanicum IFM 58214 showed the antifungal activity against Aspergillus fumigatus. The active principle from E. javanicum IFM 58214 was determined to be 2-(2-carboxyethyl)-3-decylmaleic anhydride (1), by chemical and spectroscopic method. The methyl ester (2) of 1 was identified with the semi-synthetic one derived from spiculisporic acid. Semi-synthetically prepared 1 inhibited the growth of A. fumigatus, while other related compounds showed only marginal or no activity. To our knowledge, compound (1) is the first example of identification from natural sources.