Accumulation of an unusual trichothecene shunt metabolite in liquid culture of Fusarium graminearum with methionine as the sole nitrogen source

Abstract

  Fusarium graminearum produces type B trichothecenes in liquid culture as the sole trichothecene products. When methionine was used as a nitrogen source, a considerable amount of 3-deacetylcalonectrin (3-deCAL), devoid of a C-8 ketone, accumulated in the synthetic medium as one of the major end products. This indicates that a wild-type F. graminearum type B trichothecene producer could accumulate a substantial amount of a type A trichothecene, depending on culture conditions.