Abstract
Relative acute toxicity to laboratory animals and fate of chloropeptide in mice were examined. s.c. LD50 to mice, rats and guinea-pigs was in the same range of 0.5mg/ kg, and the p.o. LD50 to mice and rats was 5-7mg/kg. A large portion of s.c. administered 3H-peptide was detected in the liver, and a few percent of p.o. administered toxin was detected in the liver. Gel-filtration of the excreta revealed that the p.o. administered toxin was excreted into the feces without a marked modification and the presence of dehydrochloropeptide was proved in the urine.
