Abstract
Cerebrovascular disorders such as cerebral aneurysms or atherosclerosis are reported to be caused by thedegeneration of arterial walls such that mechanical stresses induced by blood flow affects mass transport of theendothelial cells and then leads to hardening of arterial walls. In order to obtain a better understanding of thedegeneration of arterial walls, the authors have been developing a multi-scale and physics numerical simulation system “M-SPhyR (Multi-Scale and Physics SimulatoR) Circulation”. The paper presents the main features ofM-SphyR, which consists of three programs and the modules to connect three programs. The analyses are carried outfor three different cases: 1) multi-scale analysis for the cerebral arterial circle of Wills, 2) analysis of bloodflow-arterial wall interaction for a cerebral aneurysm, and 3) multi-physics analysis of atherosclerosis in the carotidartery. The results are compared to those by the conventional methods and are discussed for the further improvementof the simulation system.
