Abstract
Following the research exposed in Report (I) (Vol. 44. No. 4., 1955), the present report deals with the results of the examination how the intracutaneous and subcutaneous injection of some substances will influence the increase or decrease of the eosinophil cells in the local tissue and the peripheral blood.
The results are summarized as follows:
The ascaris-extract and ankylostoma-extract injected intracutaneously into the body of a human being who is in an eosinophilic condition, increase the number of eosinophil cells in the local tissue in 5 to 10 minutes after the injection. But acetyl-cholin solution and glair have weaker effect: Histamin solution, Phosphatbuffer solution (pH. 5.9 and pH. 7.6.), the serum of an ankyloatomiasis patient and physiological saline have no effect at all.
The reinjection of 1.0cc of the glair into the body of guinea pig three weeks after it became sensible with 2.0cc of the glair, will cause a speedy and marked increase in the eosinophil cells contained in the blood, local tissue and bone marrow, resulting in the development of eosinophilom in the lung.
The present report, then, gives a description of the condition of the eosinophil cells in the blood, exudate and organ-tissue in the eosinophilic case, 1) eosinophile pleuritis, 2) pulmonary acariasis which has developed Loeffler's syndrome and 3) the pancreas eosinophilom caused by ascaris eggs.
Lastly, mainly based on the results of the examination already described in the Reports I and II, a few opinions of my own have been given in the present report about such subjects as the relationship between eosinophilia and allergy or parasite diseases; the mechanism of the development of tissue-eosinophilia; the co-relativity of tissue-eosinophilia, and blood-eosinophilia, and others.
