Nihon Naika Gakkai Zasshi
Online ISSN : 1883-2083
Print ISSN : 0021-5384
ISSN-L : 0021-5384
STUDIES ON THE SERUM-ANTIBODIES OF TUBERCULOSIS
I. THE CHANGES OF γ-GLOBULIN FRACTION FOLLOWING THE ABSORPTION TESTS BY THE USE OF THE TUBERCLIN SENSITIZED RED CELLS
Hisashi Fukuzaki
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JOURNAL FREE ACCESS

1955 Volume 44 Issue 8 Pages 851-857

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Abstract

The absorption tests were made on the sera of 7 normal individuals, 30 tuberculous cases, and 7 non-tuberculous cases which showed high γ-globulin contents, by using the tuberculin sensitized red cells as absorbants and then the changes of each fraction the serum protein before and after this procedures were observed by Tiselius's electrophoretic method.
The results obtained were as follows:
1) In normal individuals, no significant change was found on the γ-globulin fraction, but the albumin fraction showed 2.4% decrease on the average.
According to writer's preliminary experiments, this seemed to be caused by the non-specific absorption by the sensitized red cells.
2) In the tuberculous cases, 2.4% decrease of γ-globulin fraction and 1.8% increase of albumin fraction observed were significant-in the sense that the specific absorption occurred more markedly than the non-specific absorption by the sensitized red cells. And at the same time, the hemagglutination titers also showed a marked decrease after the absorption tests.
3) In the non-tuberculous cases, no significant change was noted in all the fractions of the serum.
4) Absorption tests by usiog heat killed tubercle bacilli of human type were made on the tuberculous cases in parallel with the sensitized red cells, and almost the same findings were obtained.
Based on these results, it may be concluded that the some parts of the specifiic antibodies are contained in the γ-globulin fraction of the serum of tuberculous patients.

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© The Japanese Society of Internal Medicine
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