Abstract
Sogen and Kuwano in our laboratory reported recently on the results of estimation of the protein-bound iodine (PBI) in plasma in various internal diseases. They used then a simple method, modified by Heki and Sogen. The investigation on the improvement of method, however, was continued thenceforth and the report of the new precise one was published as Heki-Ono's method in the Endocrinologia japonica, 2, 99, 1955.
The author intended in this report to reinvestigate the results, obtained by Sogen and Kuwano, by this now procedure of PBI estimation.
The level of PBI in healthy adults was found to be 5.0-7.5 γ/dl; there was no overlapping of values between hyper-or hypothyroidal state and normal individuals.
In beri-beri, pulmonary tuberculosis, diabetes mellitus etc, the level was low, the results which well agreed with those by Sogen and Kuwano.
In essential hypertension the level of PBI was found to be rather low, the result which agreeded with that by Kuwano, but not with that by Sogen.
In anchylostomiasis normal values were obtained, while Sogen and Kuwano reported low levels in the same disease.
The fact of the seasonal variation of PBI in normal adults, previously reported by Kuwano, has been established.
