Nihon Naika Gakkai Zasshi
Online ISSN : 1883-2083
Print ISSN : 0021-5384
ISSN-L : 0021-5384
STUDIES ON THE PATHOGENESIS OF EXPERIMENTAL LIVERCIRRHOSIS, PRODUCED BY POISON OF “ASARI” AND “KAKI” (SHELL-FISH)
Atsushi Iwamoto
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JOURNAL FREE ACCESS

1958 Volume 47 Issue 2 Pages 124-140

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Abstract

It is known that poisoning by asari and kaki, which are thought to contain a kind of biogenetic amine, causes a typical acute yellow liver atrophy.
In this study, with observation on its development, experimental livercirrhosis has been produced in 30 mice, by intraperitoneal injection of one forth lethal dosis of this poison, every 5 days, with total 45 injections.
With one injection, central necrosis and degeneration of medial zone of the liver acinus were observed, which were completely recovered within 5 days, but in cases with 3 or 6 injections, these changes were not recovered 5 days after the last injection.
With about 9th injection, the mice became exhausted, resulting in loss of body weight and in some cases, in death.
In this stage, histological examination of the liver revealed the beginning of central fibrosis, with marked fatty infiltration but few cellular infiltration.
After the 12th injection, it was observed fibrosis progressed, with contrary decreasing of fat contents, showing various formation of pseudoacini.
In all cases of 45 injections, there was seen typical liver cirrhosis, histologically revealing bands of connective tissue surrounding the parenchyma, with mixture of destroyed and regenerated tissue.
In a case, the surface of the liver was uneven with several large protruding nodules, makroscopically resembling hepatoma, but microscopically revealing compensatory hyperplasia.
The liver cell showed marked atypia, suggesting strongly the possible way to produce hepatoma.
There have been many experiments to produce liver cirrhosis, but in this original study, experimental liver cirrhosis was made in every case, by substance similar to biogenetic amines which are known to have intimate relation with autointoxication. This study will provide a new idea to the pathogenesis of liver cirrhosis in human being.

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© The Japanese Society of Internal Medicine
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