Effects of Alzheimer's Disease on the Ability of Titanium Surface to Induce Hard Tissue Differentiation

Abstract

Alzheimer's disease is a progressive brain disorder that affects areas of the brain that control cognitive functions and memory, and the number of patients in Japan is increasing. It is important for dentists to improve the oral quality of life of Alzheimer's patients, but for that, it is necessary to know the pathology of Alzheimer's disease. In this study, we examined the effects of Alzheimer's disease on the initial adhesion of bone marrow cells and the ability to induce hard tissue differentiation. Bone marrow mesenchymal cells extracted from the femurs of 7-week-old SAM mice and C57BL / 6 mice were seeded on titanium surface. When various markers related to the initial adhesion of bone marrow cells and the ability to induce hard tissue differentiation were examined, SAM mice showed low values ​​at all measurement times. In addition, strong expression of TNF-α was observed in bone marrow cells of SAM mice seeded on titanium surface.In conclusion, it was revealed that when the bone marrow cells of the Alzheimer model mouse were seeded on titanium surface, the initial adhesion and the ability to induce hard tissue differentiation were reduced, and the hard tissue formation was inhibited.