Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Desorption and Ionization of Amino Acid Compounds Observed by Negative Ion Mode Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) using Titanium Oxide Nanoparticles
Tetsu YONEZAWATakashi ASANOMai Thanh NGUYEN
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2020 Volume 12 Issue 2 Pages 101-109

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Abstract

Surface-assisted laser desorption / ionization mass spectroscopy (SALDI-MS) in negative mode of various amino acids with commercial TiO2 nanoparticles as the DI assisting material is reported. SALDI-MS gives clear spectra of these low molecular weight negative ions, such as drugs and bio-related organic compounds. With commercially available TiO2 nanoparticles, 20 common amino acids used could be clearly detected as [M-H]- molecular ions. The ion intensity of [M-H]- molecular ions is well linear correlated with the gas-phase acidity but less correlation with the hydrophobicity. But the concentration of the amino acids on the TiO2 nanoparticle surface also affected the ion intensity.

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© 2020 Nano Biomedical Society
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