Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Antibacterial Activity and Biofilm Dispersion of an Isopropyl Methylphenol-containing Dentifrice
Chisa YOSHIKAWAMasanori HASHIMOTOKengo IWASAKIKazutoshi KAKIMOTO
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JOURNAL OPEN ACCESS

2023 Volume 15 Issue 1 Pages 1-6

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Abstract

Recently, novel antibacterial substances have been developed and added to available dentifrices. Isopropyl methylphenol (IPMP) exerts an antibacterial effect on a wide range of bacteria with biosafety, and thus, is a component recently added in the disinfectants of dentifrices. Accordingly, this study aimed to evaluate the antibacterial effect of a commercially-available IPMP-containing toothpaste on Streptococcus mutans. The antibacterial effects of different concentrations (0, 0.1, 1.0, and 10%) of the dentifrice were examined via colony-forming, biofilm formation, and dispersion assays.

The results of this study demonstrated that bacterial colonization was inhibited in culture media containing 10% dentifrice, and biofilm formation was suppressed even at relatively low dentifrice concentrations (0.1 and 1.0%), however, the removal of the biofilm that had already formed was difficult. Hence, the evaluated dentifrice was considered effective for appropriate oral care. However, the ingredients responsible for this effect need to be identified and compared with other commercial products.

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© 2023 Nano Biomedical Society

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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