Effect of Three-dimensional Culture on Yttria Powder and Cytotoxicity Evaluation of Yttrium Solution

Abstract

Yttria-stabilized zirconia (YSZ) is frequently used for many prostheses, such as implant superstructure. Ceramic materials do not cause problems, such as the elution of metal ions related to corrosion in the oral cavity, differing from metallic materials. Many studies reported the biological properties of zirconia. In addition, its biological safety is relatively high, and its cytotoxicity is weak. However, many studies indicated problems on the biological properties of yttria contained at 2 to 3%. We conducted a cytotoxicity test of yttria powder using a three-dimensional culture method with collagen and cytotoxicity test of yttrium. As a result, the cytotoxicity of these substances was weak, suggesting that this element is not problematic from the viewpoint of cytotoxicity in comparison with metal ions that have been used in the field of dentistry. However, its detailed, multifaceted biological influence should be investigated in the future, considering the inhalation of dust related to dental technology operations and long-term use in the oral cavity for dental purposes.