Alterations in Antibacterial Properties and Cellular Uptake of Platinum Nanoparticles Mixed with Various Metal Nanoparticles

Abstract

This study investigates the cellular uptake and antibacterial properties of metal nanoparticles (MNPs). MNPs, such as AgNPs, PtNPs, and ZnONPs, are known for their enhanced physicochemical properties due to their large surface area. AgNPs possess broad-spectrum antibacterial properties, while PtNPs are used for their catalytic and antioxidant properties. ZnONPs are utilized in various industries for their antibacterial and UV absorption properties. The study aimed to improve the effects of AgNPs and ZnONPs by mixing them with PtNPs. TEM observations confirmed the uptake of MNPs into lysosomes. Pt-AgNPs significantly reduced biofilm formation, while Pt-ZnONPs did not show sufficient efficacy. Future research should focus on optimizing the mixing ratio and particle size to balance antimicrobial efficacy and safety.