Mutagenicity Risk of the Multi-walled Carbon Nanotubes (MWCNTs) Using the Three-dimensional Cell Culture Medium with the Umu-test

Abstract

Carcinogens are mostly mutagens that cause genetic abnormalities as cancer initiators. Multi-walled carbon nanotubes (MWCNTs) have been demonstrated to be mutagenic in many animal experiments. In the present study, we examined the mutagenicity of MWCNTs using an umu test for mutagenicity screening and the leakage of mutagens from MWCNTs, secondary to the exposure of cultured cells to MWCNTs, demonstrating no mutagenicity, although some values were nearly positive.