2016 Volume 8 Issue 2 Pages 83-90
Tumor vasculature has a key role in supplying the oxygen and nutrients. Angiogenesis is necessary for tumor growth, survival, and metastasis, therefore, the suppression of tumor angiogenesis is one of the strategies to suppress the tumor growth. TZT-1027, an anti-microtubule agent, has not only cytotoxicity against cancer cells but also inhibitory effects against tumor vasculature. We estimated the effect of combination of TZT-1027 and X-ray on tumor angiogenesis. Human endothelial cells (HUVEC and ECV304 cell line) were irradiated by 4MV X-ray. The invasive, migration and tube forming capabilities of human endothelial cells were significantly suppressed by TZT-1027 with pre-irradiation. However, the cells administrated regent after irradiation did not inhibit the capabilities significantly. In this study, we found that combination with TZT-1027 and irradiation exhibited synergistic effects of anti-angiogenesis. These results suggest the possibility that TZT-1027 in the combination with irradiation is one of strategy against cancer treatments.
