Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Inference of Embryotoxicity of Titanium Alloy Composition Metal Chemicals as an Oral Implant Body with EST Protocol
Koichi IMAITsubasa SHIRAIHiroki ISHIKAWATamaki NAKANISHIShosuke MORITA
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2017 Volume 9 Issue 1 Pages 9-14

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Abstract

The risks of embryotoxicity of pure Ti and Ti alloys used as oral implant materials have not been sufficiently elucidated. The embryonic stem cell test (EST), which allows screening of the fetal teratogenicity of chemical substances, has already been demonstrated to show high predictability by international validation, mainly in Europe. We evaluated the embryotoxicity levels of constituent element ions (Ti, V, Al, Nb, Ta, and Zr) of implants using the EST. As a result, the V ion was found to be associated with some embryotoxicity risks, while the other metal ions showed no embryotoxicity. As previously demonstrated, the V ion shows marked cytotoxicity and carcinogenicity. Therefore, Ti alloys without V ions, such as Ti-6Al-7Nb, should be widely used as implant materials.

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© 2017 Nano Biomedical Society
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