Estimation of Controlled Drug-release Behavior of Nano-porous Silica                    Micro Particles and Their Biocompatibility

Eri SEITOKU; Yuko ERA; Ko NAKANISHI; Yosuke BANDO; Shinichi KAKUDA; Koichi NAKAMURA; Teruo KUSAKA; Shigeaki ABE; Mariko NAKAMURA; Yasutaka YAWAKA; Junichiro IIDA; Yasuhiro YOSHIDA; Hidehiko SANO

doi:10.11344/nano.9.112

ORIGINAL ARTICLES

Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility

Eri SEITOKU, Yuko ERA, Ko NAKANISHI, Yosuke BANDO, Shinichi KAKUDA, Koichi NAKAMURA, Teruo KUSAKA, Shigeaki ABE, Mariko NAKAMURA, Yasutaka YAWAKA, Junichiro IIDA, Yasuhiro YOSHIDA, Hidehiko SANO

Author information

Eri SEITOKU
Graduate School of Dental Medicine,
Department of Restorative Densistry, Fucalty of Dental Medicine,
Yuko ERA
Graduate School of Dental Medicine,
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
Ko NAKANISHI
Department of Orthodontics, Fucalty of Dental Medicine,
Yosuke BANDO
Graduate School of Dental Medicine,
Department of Orthodontics, Fucalty of Dental Medicine,
Shinichi KAKUDA
Department of Restorative Densistry, Fucalty of Dental Medicine,
Koichi NAKAMURA
Department of Dentistry for Children and Disabled Person, Fucalty of Dental Medicine, Hokkaido University, Sapporo, Japan
Teruo KUSAKA
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
Shigeaki ABE
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
Mariko NAKAMURA
School of Health Science, Kyushu University of Health and Welfare, Nobeoka, Japan Japan
Yasutaka YAWAKA
Department of Dentistry for Children and Disabled Person, Fucalty of Dental Medicine, Hokkaido University, Sapporo, Japan
Junichiro IIDA
Department of Orthodontics, Fucalty of Dental Medicine,
Yasuhiro YOSHIDA
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
Hidehiko SANO
Department of Restorative Densistry, Fucalty of Dental Medicine,

Keywords: nano-porous silica, controlled drug release, glass ionomer cement

JOURNAL FREE ACCESS

2017 Volume 9 Issue 2 Pages 112-116

DOI https://doi.org/10.11344/nano.9.112

Details

Abstract

In this study, we investigated the controlled release behavior of a model drug from nanoporous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.

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