Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility
Eri SEITOKUYuko ERAKo NAKANISHIYosuke BANDOShinichi KAKUDAKoichi NAKAMURATeruo KUSAKAShigeaki ABEMariko NAKAMURAYasutaka YAWAKAJunichiro IIDAYasuhiro YOSHIDAHidehiko SANO
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2017 Volume 9 Issue 2 Pages 112-116

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Abstract

In this study, we investigated the controlled release behavior of a model drug from nanoporous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.

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© 2017 Nano Biomedical Society
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