Abstract
SynopsisWe discuss here the construction of tubular nanostructures (abbreviated as “organic nanotubes”) self-assembled from amphiphilic molecules and their utilizations. The organic nanotubes self-assembled from wedge-shaped molecules have different inner and outer surfaces covered with different functional groups. The unique properties of the organic nanotubes afforded us to demonstrate effective and selective encapsulation of guest, such as fluorescent molecules, proteins, and DNA via electrostatic interactions between the tube and the guests. In addition, selective functionalization of inner surfaces of the nanotubes visualized the dynamic behavior of the guest encapsulation, and thereby revealed that the nanotubes are able to stabilize proteins against thermal and chemical denaturation. The nanotubes also release the guest molecules when triggered by external stimuli, such as heating or pH change. These properties are applicable to utilization of the nanotubes for intelligent capsule for unstable biomaterials, drugs, and functional materials.
