The functional diversity and clinical significance of GSK3β in glioma
2018 Volume 25 Issue 1 Pages 1-9
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2018 Volume 25 Issue 1 Pages 1-9
Glycogen synthase kinase 3β (GSK3β), a serine/threonine protein kinase, has various targets involved in numerous cellular functions such as metabolic and signaling pathways as well as modification of structual proteins. Recent studies have revealed that aberrant regulation of GSK3β mediates glucose intolerance, inflammation and fibrosis, neurodegenerative disorders and the malignant phenotypes of various human cancers including glioma. This review focuses on the pathophysiological roles of GSK3β contributing to glioma biology and potential therapeutic impact of targeting GSK3β in malignant glioma.
