Effects of Kallidinogenase (human urine) (SK-827) on the Common Carotid Hemodynamics in Patients with Old Cerebral Thrombosis

Abstract

This study was performed to clarify the effects of kallidinogenase (human urine) (SK-827) on the common carotid hemodynamics in patients with old cerebral thrombosis.
A total of 11 patients including 6 males and 5 females were examined in this study, with ages ranging from 65 to 78 years (mean: 72 years) . Six patients were intravenously administered 0.15 PNA (p-nitro-aniline) units for 30 minutes and the other 5 were administered 0.30 PNA units in the same way. The common carotid hemodynamics was evaluated by ultrasonic quantitative flow measurement system (QFM-1000) before administration and 15, 30, 60 and 120 minutes after administration. Mean blood flow and mean blood velocity of the common carotid artery showed a significant increase, while cerebral circulatory resistance showed a significant decrease at 15 and 30 minutes after SK-827 administration. There were no differences between administration of 0.15 PNA units and 0.30 PNA units in the effects of SK-827 on the common carotid hemodynamics.
These results indicate that intravenous SK-827 administration may have beneficial effects on the common carotid hemodynamics in patients with old cerebral thrombosis.