Reactions of 1.3-Dicarbonyl Compounds with Hexamethylenetetramine —Facile Synthetic Method for 1,4-Dihydropyridine Derivatives and Their Air Oxidation—

Abstract

The reaction of acetoacetates or benzoylacetone with hexamethylenetetramine in aqueous ammonium carbonate solution at room temperature gave 2,6-dimethyl-1,4-dihydropyridines (DHP) directly. These DHPs were oxidized to the corresponding pyridine derivatives quantitatively by air oxidation. Reaction machanism is also discussed.