NIPPON KAGAKU KAISHI
Online ISSN : 2185-0925
Print ISSN : 0369-4577
Activation of Fibroblast Growth Factors by Bioinspired Glycopolymers
Kenichi HATANAKAFumie KURIHARAMegumi KUNOUAkihiro OKUDAMaria Carmelita KASUYAMitsuru AKASHI
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2002 Volume 2002 Issue 2 Pages 155-158

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Abstract

Sulfated poly[2-(glucosyloxy)ethyl methacrylate] (degree of sulfation = 1.07, 2.13, 3.86), which was bioinspired glycopolymer, was synthesized by polymerization of 2-(glucosyloxy)ethyl methacrylate followed by sulfation of the obtained polymer. Effects of the sulfated poly[2-(glucosyloxy)ethyl methacrylate]s with various degree of sulfations on the cell proliferation activity of fibroblast growth factors (FGFs). Sulfated poly[2-(glucosyloxy)ethyl methacrylate]s with higher and lower degree of sulfations activated FGF-1 and FGF-2, respectively.

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© 2002 The Chemical Society of Japan
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