1973 Volume 1973 Issue 11 Pages 2242-2244
Synthesis of unsymmetric N, N> -disubstituted amidinoformic acid (7) by the reaction of N-substituted derivative (2) with amines at an elevated temperature was unsuceessful due to easy decarboxylation of (2), however, (7) was smoothly obtained by condensation of N-substitutedthiooxamidic acid (6) with amines in methanol at a room temperature in the presence of mercuric oxide. Compound (6) was obtained by condensation of potassium thiooxamidate (1)and amines in a large amount of water, and successive extraction of the acidified reaction mixture with ether.
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