Catalytic Methylation of α -Picoline with Methanol

Abstract

The vapor phase sqtalyt-ic-methylation of ev-picoline with methanol has been studied in a flow system using solid acid, base and acid-base catalysts over a range of temperatures fr6n1400 to 530 C under atmospheric pressure.
On Shes. e cat. a.1. ystsAthg 14. ajor. liquid-produ. cts obtained were 2, 6-lutidine along with small amounts of pyridine, B-picoline, 2, 4 and 2, 5-lutidines and 2, 4, 6-collidine. The Torder of the gatalytic qctivity wqs silica Tnagnesuzia silica-alumina kk T-alumina fluorinated rm T: al miKaV magnesium phosphate. Silica gel, magnesia and calcia were virtually inactive.