The Reaction of Arylbiguanide with Excess of Benzoyl Chloride

Abstract

4-Anilino-2-benzamido-6-phenyl-1, 3, 5-triazine [2 a] and N², N⁴, N⁵-tribenzoyl-N¹-phenyl- biguanide [3 a] were obtained by the reaction of N¹-phenylbiguanide with excess of benzoyl chloride in acetone. Similarly 2-benzamido-4 (substituted anilino) -6-phenyl-1, 3, 5-triazine [2 b- 2 d and 2 f] and N², N⁴, N⁵-tribenzoyl-N¹- (substituted phenyl) biguanide [ 3b-3d and 3f]were obtained by the reaction of n¹- (p-tolyl) biguanide, N¹-(p-methoxyphenyl) biguanide, N¹- (p-chlorophenyl) biguanide and N¹- (m-nitrophenyl) biguanide with benzoyl chloride, respectively. The properties of the products are shown in Table 2 and Table 3. [2 a] and 2-amino- 4-anilino-6-phenyl-1, 3, 5-triazine [1 a] were obtained by the hydrolysis of [3 a]. N², N⁴, N⁵-Tetrabenzoyl-N¹-phenylbiguanide was obtained by the reaction of [3 a] with benzoic anhydride.