NIPPON KAGAKU KAISHI
Online ISSN : 2185-0925
Print ISSN : 0369-4577
N-Alkylation of Amines and Amides Catalyzed by Ammonium Halides
Hiroshi KASHIWAGISaburo ENOMOTO
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1980 Volume 1980 Issue 2 Pages 279-281

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Abstract

A new method was found for N-alkylation of amines and amides with alcohols in homogeneous liquid-phase. Addition of small amounts of ammonium halide to the reactants attained successfully high yields of N-alkyl or N, N-dialkyl derivatives of starting amines and amides at 280-320°C in the atmosphere of nitrogen. This N-alkylation reaction gave N, N-dialkylaniline from aniline, N-alkyl-α-pyrrolidone from α-pyrrolidone, N-alkyl-α-piperidone from α-piperidone, N, N-dialkylformamide from formamide (starting material : ammonium formate), and N, N-dialkylacetamide from acetamide (starting material : ammonium acetate).

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