Synthesis of N, N′-Dithiobis(amines) from Hindered Amines

Abstract

A convenient synthetic method has been developed for the preparation of N, N′-dithiobis-(amines) from hindered amines : the reaction of 2, 2, 6, 6-tetramethyl-4-piperidinoile [1a] with S₂Cl₂-DMF in the presence of sodium acetate in hexane at 5-10°C gave bis(2, 2, 6, 6-tetramethyl-4-oxopiperidine-1-yl) disulfide [2a] in a good yield. Under the same reaction conditions, disulfides [2b-e] of other hindered amines were obtained.