An Alternative Synthesis of Carboxylic Acids from Grignard Reagents

Abstract

An alternative method for carboxylation of the Grignard reagents was developed. Both aromatic and aliphatic Grignard reagents gave the corresponding carboxylic acids in moderate yields by the reaction with pentacarbonyliron followed by treatment with iodine-water. The secondary alkyl Grignard reagents gave the acids rather in low yields.