Synthesis of Oligosaccharide Asparagine Compounds

Abstract

N-(4-L-Asparty1)-β-gentiobiosyl-, -isomaltosyl-, and -manninotriosylamines were synthesized in order, . t o provideu sefulmodelc ompoundfso r studieso n nephritogenosidieso latedb y Shibata et al from the glomeruler, basement membrane of rats.
The desired compounds were synthesized from the corresponding fully acetylated glycosyl bromides via the following steps: aide formation, reduction 'to glycosylamine, condensation with: protected L-aspartic acid, followed by removal of the protecting groups.