Regioselective Protect i o n of Kanamycin A with the Aid of Phase Transfer Catalysis-Synthesis of 3'-Deoxy-2'-epikanamycin A

Abstract

Selective 2''-O-benzoylation of 4'-O-tetrahydropyranyl-4'', 6''-O-c yclohexylidene-tetrakis(N-ethotycarbonyl)kanamycin A with the aid of phase transfer catalysis and synthesis of 3'-deoxy2'-epikanamycin A vici-O-tetrallydropyranyl-2''-O-benzoyl-4'', 6''-O-cyclohexylidene-tetrakis (N-pthoxycarbonyl)kanamycin A are described.