Solubility Measurements of Solid Organic Compounds in Water by TOC Method

Abstract

Kitakaname, Hiratsuka-shi 259-12 Japan The solubility of organic compounds in pure water was measured by means of TOC (Total Organic Carbon) method, and sufficient results were obtained. In the begining, a saturated solution of organic compounds was prepared, the TOC of the saturated organic compounds in water was measured, subsequently solubility of compounds was determined from the TOC values. The TOC values were measured by the use of a TOC measuring instrument (SHIMAZUTOC-10B).
Also, the method for the preparation of saturated solution at 20°C was established. In order to dissolve organic compounds in water, the shaking condition was studies (Fig.1-3). Moreover, when the solution that was shaken was allowed to remain in a stationary state, the variation of concentration of organic compounds as the stationary time increased was measured (Fig.4, 5). From the results of these experiments, it is found that following is the most desirable method to obtain the saturated solution. That is, after adding organic compounds in water at 50°C, the solution was shaken for 5 minutes, and the solution is permitted to stand for 48 h at 20°C. By the method described above, the solubility of organic compounds, that is above 10 μg/m/, was measured in a short time, directly, simply and very accurately and that is not necessary to use extraction and other complex procedures.