Antibacterial Activity of Vinyl Monomers Having a Pyrrolidinone Structure

Abstract

In order to obtain a new pharmcologically active polymer, 1-aryl-5-(3-methoxy-4-hydroxyphenyl)2-oxopyrrolidine-4-carboxylic acid [2]and their methacrylates [3]were prepared. The ammonium salts of [2] and [3] were submitted to the antibacterial activity test to Bacillus polymyxa strain Hino using a modified Winogradsky's medium. Triethylammonium 5-[3-meththoxy-4-(methacryloyloxy)phenyI]-1-tolyl-2-oxopyrrolidine-4-carboxylate[7b] show-ed the highest antibacterial activity.