Melamine-Anhydrous Hydrogen Fluoride Solution as a Highly Effective and Convenient Hydrofluorination Reagent

Abstract

Solutions containing 14∼23% weight percent of melamine in anhydrous hydrogen fluoride have been found to be stable and more convenient fluorinating agents for alkenes and alcohols, being superior to other organic amine-hydrogen fluoride reagents. The reagent with such a co-solvent as pentane or carbon tetrachloride, which forms a liquid-liquid two phase mixture, revealed to be a versatile and highly advantageous system for a repeated use in continuous hydrofluorination of alkenes.