Palladium-catalyzed Reaction of Aryl Bromide with Aryltributyltin Preparation of Unsymmetrically-substituted B iaryls

Abstract

Palladium-catalyzed reaction of aryl bromide, ArBr, with aryltributyltin, Ar'SnBu₃, was found to be useful for the synthesis of the unsymmetrically-substituted biaryl, ArAr', except for the reaction with o-substituted aryl tributyltin. In some cases, a small amount of by-product, Ar'Ph, was formed by participation of the ligand, PPh3, on palladium. Substituent effects of substrates and reagents on the reaction rate were also investigated. The former was considerably large, whereas the latter was small.